Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition
L. S. Arabanian, J. Adamsson, A. Unger, R. Di Lucrezia, T. Bergbrede, A. Ashouri, E. Larsson, P. Nussbaumer, B. M. Klebl, L. Palmqvist, C. M. Gustafsson
This study shows that inhibiting mitochondrial transcription with IMT sensitizes acute myeloid leukemia cells to BCL-2 inhibition, enhancing apoptosis and survival in mouse models.
bioRxiv · Sep 23, 2022 · PreprintCancer Biology