Author

A. Unger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:development & morphogenesis· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. Bergbrede· 2 shared W. A. Linke· 2 shared Y. Li· 2 shared A. Ashouri· 1 shared A. Fernandez-Trasancos· 1 shared A. Fischer· 1 shared A. Krook· 1 shared A. L. Hessel· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersPhysiology

T. Bergbrede

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

S. Jiang, T. Yuan, L. S. Kremer, F. A. Rosenberger, F. M. Hansen, M. Borg, D. Rubalcava-Gracia, M. Mennuni, R. Filograna, D. Alsina, J. Misic, C. Koolmeister, L. Ren, O. Andersson, A. Unger, , N.-G. Larsson

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

bioRxiv · Sep 22, 2023 · PreprintPhysiology

Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

L. S. Arabanian, J. Adamsson, A. Unger, R. Di Lucrezia, T. Bergbrede, A. Ashouri, E. Larsson, P. Nussbaumer, B. M. Klebl, L. Palmqvist, C. M. Gustafsson

This study shows that inhibiting mitochondrial transcription with IMT sensitizes acute myeloid leukemia cells to BCL-2 inhibition, enhancing apoptosis and survival in mouse models.

bioRxiv · Sep 23, 2022 · PreprintCancer Biology

Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity

M. Shahriyari, M. Islam, M. Sakib, A. Rika, D. Krueger, L. Kaurani, H. Anandakumar, O. Shomroni, M. Schmidt, G. Salinas, A. Unger, W. Linke, J. Zschuentzsch, J. Schmidt, A. Fischer, , M. Tiburcy

This study develops a human hypaxial muscle model from pluripotent stem cells with functional maturation and regenerative capacity for studying muscle biology and disease.

bioRxiv · Jul 12, 2021 · PreprintCell Biology

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

Y. Li, A. L. Hessel, A. Unger, D. Ing, J. Recker, F. Koser, J. K. Freundt, W. A. Linke

This study uses a titin-cleavage mouse model to show that titin cleavage reduces passive and active forces and disrupts A-band stability during muscle contraction.

bioRxiv · Oct 27, 2020Cell Biology

A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues

J. A. Rivas-Pardo, Y. Li, Z. Martonfalvi, R. Tapia-Rojo, A. Unger, A. Fernandez-Trasancos, E. Herrero-Galan, D. Velazquez-Carreras, J. M. Fernandez, W. A. Linke, J. Alegre-Cebollada

The paper introduces a HaloTag-TEV genetic cassette to study protein mechanics in native tissues, showing titin's role in muscle contraction under mechanical forces.

bioRxiv · Jan 17, 2020Biophysics