Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
A. U. Malik, A. Karapetsas, R. S. Nirujogi, S. Mathea, P. Pal, P. Lis, M. Taylor, E. Purlyte, R. Gourlay, M. Dorward, S. Weidlich, R. Toth, N. K. Polinski, S. Knapp, F. Tonelli, D. R. Alessi
This study identifies distinct Rab proteins phosphorylated by LRRK1 and LRRK2, showing they are regulated by different mechanisms and respond differently to inhibitors.
bioRxiv · Nov 25, 2020Biochemistry