M. Taylor

Environmental DNA reveals fine scale spatial and temporal variation of prey species for marine mammals in a Scottish marine protected area

This study uses eDNA metabarcoding to track spatiotemporal changes in prey species for marine mammals in a Scottish MPA, revealing patterns in forage fish abundance and predator-prey spatial partitioning.

Correlations in microbial abundance data reveal host-bacteria and bacteria-bacteria interactions jointly shaping the C. elegans microbiome

The paper analyzes microbial abundance data in C. elegans to assess host-bacteria and bacteria-bacteria interactions, finding that neither model alone fully explains the observed correlations.

Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4

This study investigates how inflammation and IL-4 regulate LRRK2 expression and activity in immune cells, revealing cell-specific effects and the role of the LRRK2-R1441C mutation.

In vivo Safety and Immunoactivity of Oncolytic Jurona Virus in Hepatocellular Carcinoma: A Comprehensive Proteogenomic Analysis

This study evaluates the in vivo safety and immunoactivity of Jurona virus in hepatocellular carcinoma using proteogenomic analysis, showing tumor regression and enhanced immune responses.

Sample pooling inflates error rates in between-sample comparisons: an empirical investigation of the statistical properties of count-based data

The paper investigates how sample pooling affects statistical inference in count-based data, finding that batch-based analysis leads to false positives and negatives in comparisons between groups.

Enhancement of mitochondrial function fosters B cell immune memory

This study shows that enhancing mitochondrial function with Mdivi-1 improves memory B cell differentiation and vaccine efficacy against influenza and SARS-CoV-2.

The Actin Bundling Protein Fascin Promotes Lung Cancer Growth and Metastasis by Enhancing Glycolysis and PFKFB3 Expression

This study shows that fascin promotes lung cancer growth and metastasis by enhancing glycolysis through YAP1-PFKFB3 activation.

PTPN14, a modifier of HHT, protects SMAD4 from ubiquitination and turnover to potentiate BMP9 signaling in endothelial cells.

This study identifies PTPN14 as a stabilizer of SMAD4, enhancing BMP9 signaling in endothelial cells and suggesting potential drug targets for HHT.

In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth.

This study identifies concurrent Wnt and PI3K activity as drivers of invasive cholangiocarcinoma growth and shows that their co-inhibition slows tumor growth in vivo.

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

This study identifies distinct Rab proteins phosphorylated by LRRK1 and LRRK2, showing they are regulated by different mechanisms and respond differently to inhibitors.

Host immunity alters successional ecology and stability of the microbiome in a C. elegans model

This study shows that genetic differences in innate immunity in C. elegans alter microbiome composition, diversity, and stability by changing ecological processes.

Sound generation in zebrafish with Bio-Opto-Acoustics (BOA)

This study introduces BOA stimulation to controllably activate specific otolith organs in zebrafish larvae, revealing their cooperative role in hearing.

Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype

This study identifies molecular changes in skeletal muscle caused by breast cancer, showing mitochondrial dysfunction across subtypes and no effect of treatment on gene expression.

A cellular automaton for modeling non-trivial biomembrane ruptures

This paper introduces a cellular automaton model to simulate biomembrane ruptures, showing it can replicate complex rupture patterns and reveal the role of inter-layer adhesion.