Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
M. Solvay, P. Pfander, S. Klaessens, L. Pilotte, V. Stroobant, J. Lamy, S. Naulaerts, Q. Spillier, R. Frederick, E. De Plaen, C. Sers, C. A. Opitz, B. J. Van den Eynde, J. Zhu
This study shows that tryptophan depletion increases AHR expression and kynurenine uptake, enhancing AHR activation and promoting regulatory T cell differentiation.
bioRxiv · Jan 16, 2023Cell Biology