Cell BiologybioRxiv
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
M. Solvay, P. Pfander, S. Klaessens…·J. Zhu
This study shows that tryptophan depletion increases AHR expression and kynurenine uptake, enhancing AHR activation and promoting regulatory T cell differentiation.
DOI 10.1136/jitc-2023-006728