Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1
M. H. Ward, Z. C. Nwosu, P. Poudel, S. Kasperek, Z. Tolstyka, R. E. Menjivar, C. Ragulan, G. Nyamundanda, L. Zhang, A. Andren, C. J. Halbrook, E. S. Carpenter, M. Pasca di Magliano, A. Sadanandam, C. A. Lyssiotis
This study identifies uridine as a novel nutrient for pancreatic cancer cells through uridine phosphorylase 1, showing its role in survival and metabolism under glucose deprivation.
bioRxiv · Jun 7, 2021 · PreprintCancer Biology