Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication - transcription conflicts
S. Scaramuzza, M. Muste Sadurni, D. Poovathumkadavil, T. Natsume, P. Rojas, M. T. Kanemaki, M. Saponaro, A. Gambus
This study identifies TRAIP's role in preventing DNA damage during S-phase by resolving replication-transcription conflicts, leading to cell cycle arrest and senescence upon TRAIP depletion.
bioRxiv · Mar 23, 2022 · PreprintCell Biology