T. Natsume

This study identifies a direct relationship between viral protein expression and progeny yield in herpes simplex virus 1, revealing DNA cleavage/packaging as a rate-limiting step for virus production.

This study characterizes replisome disassembly in human cells, showing that Cullin2, LRR1, and p97 are required, and that replication stress occurs with inhibitor treatment.

This study identifies TRAIP's role in preventing DNA damage during S-phase by resolving replication-transcription conflicts, leading to cell cycle arrest and senescence upon TRAIP depletion.

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

This study shows NUDT21 connects RLRs in stress granules to mitochondrial IPS-1, enabling antiviral defense by facilitating type I IFN induction.

This paper improves AID technology by introducing new plasmids and auxinole to control degron-fused protein degradation in human cells.

This study uses optogenetic reconstitution to show that NuMA clusters Dynein-Dynactin to generate cortical spindle-pulling forces through multi-arm interactions.

This study shows Ki-67 and condensins have independent yet cooperative roles in maintaining mitotic chromosome structure through distinct mechanisms.