Author

A. Gambus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

D. Poovathumkadavil· 2 shared S. Scaramuzza· 2 shared T. Natsume· 2 shared A. L. B. Pyne· 1 shared A. Skagia· 1 shared C. Ward· 1 shared D. Blakemore· 1 shared D. Racko· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

D. Poovathumkadavil

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Under or Over? Tracing Complex DNA Structures with High-Resolution Atomic Force Microscopy

E. P. Holmes, M. C. Gamill, J. I. Provan, L. Wiggins, R. Ruskova, S. Whittle, T. E. Catley, K. H. S. Main, N. Shephard, H. E. Bryant, N. S. Gilhooly, A. Gambus, D. Racko, S. D. Colloms, A. L. B. Pyne

This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.

bioRxiv · Jun 28, 2024Biophysics

Characterising replisome disassembly in human cells

R. Jones, J. Herrero Ruiz, S. Scaramuzza, S. Nath, M. Henklewska, T. Natsume, F. Romero, M. Kanemaki, A. Gambus

This study characterizes replisome disassembly in human cells, showing that Cullin2, LRR1, and p97 are required, and that replication stress occurs with inhibitor treatment.

bioRxiv · Jul 12, 2022Cell Biology

Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication - transcription conflicts

S. Scaramuzza, M. Muste Sadurni, D. Poovathumkadavil, T. Natsume, P. Rojas, M. T. Kanemaki, M. Saponaro, A. Gambus

This study identifies TRAIP's role in preventing DNA damage during S-phase by resolving replication-transcription conflicts, leading to cell cycle arrest and senescence upon TRAIP depletion.

bioRxiv · Mar 23, 2022 · PreprintCell Biology

The p97 cofactor Ubxn7 facilitates replisome disassembly during S-phase

Z. Tarcan, D. Poovathumkadavil, A. Skagia, A. Gambus

This study identifies Ubxn7 as a p97 cofactor that facilitates replisome disassembly during S-phase by interacting with both Cul2Lrr1 and p97.

bioRxiv · Dec 16, 2021 · PreprintBiochemistry

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells

D. Blakemore, R. Almaghrabi, N. Vilaplana, E. Gonzalez, M. Moya, C. Ward, G. Murphy, A. Gambus, E. Petermann, G. Stewart, P. Garcia

This study shows MYBL2 activates ATM to suppress replication stress in ESCs, with loss of MYBL2 or ATM causing replication fork slowing and increased origin firing.

bioRxiv · Jun 4, 2020Cell Biology