Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development
M. L. Fichtner, C. Vieni, R. Redler, L. Kolich, R. Jiang, K. Takata, P. Stathopoulos, P. Suarez, R. J. Nowak, S. J. Burden, D. Ekiert, K. C. O'Connor
The paper investigates how self-antigen-driven affinity maturation contributes to the development of pathogenic monovalent IgG4 autoantibodies in myasthenia gravis, showing that high-affinity Fab-arm exchanged antibodies require specific mutations for pathogenic capacity.
bioRxiv · Mar 14, 2020Immunology