R. Jiang

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Plastome-based Phylogenomic analyses provide insights into the germplasm resource diversity of Cibotium in China

This study uses plastome data to analyze the genetic diversity and phylogeny of Cibotium species in China, identifying cryptic species and lineage differentiation to aid conservation and breeding efforts.

Titering of Chimeric Antigen Receptors on CAR T Cells enabled by a Microfluidic-based Dosage-Controlled Intracellular mRNA Delivery Platform

This paper introduces a microfluidic platform for controlled delivery of CAR gene mRNA to T cells, enabling titering of CAR expression on their surface.

3D Confinement-enabled Priming of Synaptic Activation Promotes Primary T Cell Expansion

This paper introduces a 3D confinement method to prime T cell-MHC immune synapses, achieving faster T cell expansion compared to conventional methods.

Maximum Classifier Discrepancy Generative Adversarial Network for Jointly Harmonizing Scanner Effects and Improving Reproducibility of Downstream Tasks

This paper introduces MCD-GAN, a method that harmonizes scanner effects in MRI data while preserving biological information, improving cross-scanner classification performance.

Plant protoplast-based assay to screen for salicylic acid response-modulating bacteria

The paper develops a plant protoplast-based assay to measure real-time gene expression changes in response to bacterial inoculation, enabling high-throughput screening of salicylic acid-modulating bacteria.

Coupled functional physiological phenotyping and simulation model to estimate dynamic water use efficiency and infer transpiration sensitivity traits

Kinesin-1, -2 and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

The paper investigates how kinesin-1, -2, and -3 motors compete with dynein during bidirectional transport and finds that all three families can withstand hindering loads through distinct kinetic strategies.

Porphyrin overdrive rewires pan-cancer cell metabolism

This study identifies porphyrin overdrive as a universal metabolic rewiring in cancer cells, showing its role in oncogenic growth and demonstrating a novel 'bait-and-kill' strategy to target it.

Crystal Structure of Caskin1/CASK complex reveals the molecular basis of the binding specificity of CASK_CAMK domain and its binding partners

The paper determines the crystal structure of the Caskin1/CASK complex, revealing the molecular basis of CASK_CAMK domain binding specificity and identifying new potential binding partners.

Evaluation of different concentrations antibiotics on gut bacteria and growth of Ectropis obliquaProut (Lepidoptera: Geometridae)

This study evaluates antibiotic concentrations affecting gut bacteria and Ectropis obliqua growth, finding 300g/ml effectively clears bacteria without harming growth.

Elevated N-glycosylation of immunoglobulin G variable regions in myasthenia gravis highlights a commonality across autoantibody-associated diseases

This study identifies elevated N-glycosylation in IgG variable regions in myasthenia gravis patients and shows it is not required for autoantigen binding.

High-throughput and dosage-controlled intracellular delivery of large cargos by an acoustic-electric micro-vortices platform

The paper introduces a microfluidic platform for high-throughput, dosage-controlled intracellular delivery of large cargos with high viability and efficiency.

Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform of cancer screening for early detection of cancer

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

This study identifies a unique GCN5 histone acetyltransferase complex in Plasmodium falciparum that regulates erythrocyte invasion and virulence by modulating chromatin states and gene expression.

Human B cell lineages engaged by germinal centers following influenza vaccination are measurably evolving

The paper shows that influenza vaccination leads to measurable evolution in B cell lineages engaged by germinal centers, but not in blood lineages.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Glycyrrhizic acid improves cognitive levels of aging mice by regulating T/B cell proliferation

This study shows that glycyrrhizic acid improves cognitive function in aged mice by enhancing T and B cell proliferation and blood perfusion.

Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development

The paper investigates how self-antigen-driven affinity maturation contributes to the development of pathogenic monovalent IgG4 autoantibodies in myasthenia gravis, showing that high-affinity Fab-arm exchanged antibodies require specific mutations for pathogenic capacity.

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses

The paper identifies persistent autoantibody-producing B cell clones in rituximab-treated myasthenia gravis patients during relapses, showing incomplete B cell depletion.

Microtubule Binding Kinetics of Membrane-bound Kinesin Predicts High Motor Copy Numbers on Intracellular Cargo

The paper measures the microtubule binding kinetics of membrane-bound kinesin-1 motors and finds that motor reattachment is not limited by diffusion but by intrinsic binding rates, predicting high motor copy numbers for long-range vesicle transport.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.