Author

R. Redler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Ekiert· 3 shared D. Baker· 2 shared G. Bhabha· 2 shared T. Brunette· 2 shared A. Broerman· 1 shared A. Courbet· 1 shared A. J. Borst· 1 shared A. K. Bera· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiochemistry

D. Ekiert

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Blueprinting expandable nanomaterials with standardized protein building blocks

T. F. Huddy, Y. Hsia, R. D. Kibler, J. Xu, N. Bethel, D. Nagarajan, R. Redler, P. J. Y. Leung, A. Courbet, E. C. Yang, A. K. Bera, N. Coudray, S. J. Calise, F. A. Davila-Hernandez, C. Weidle, , D. Baker

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

bioRxiv · Jun 9, 2023Biochemistry

De novo design of modular peptide binding proteins by superhelical matching

K. Wu, H. Bai, Y.-T. Chang, R. Redler, K. E. McNally, W. Sheffler, T. Brunette, D. R. Hicks, T. E. Morgan, T. J. Stevens, A. Broerman, I. Goreshnik, M. DeWitt, C. M. Chow, Y. Shen, , D. Baker

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

bioRxiv · Nov 14, 2022 · PreprintBiochemistry

Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development

M. L. Fichtner, C. Vieni, R. Redler, L. Kolich, R. Jiang, K. Takata, P. Stathopoulos, P. Suarez, R. J. Nowak, S. J. Burden, D. Ekiert, K. C. O'Connor

The paper investigates how self-antigen-driven affinity maturation contributes to the development of pathogenic monovalent IgG4 autoantibodies in myasthenia gravis, showing that high-affinity Fab-arm exchanged antibodies require specific mutations for pathogenic capacity.

bioRxiv · Mar 14, 2020Immunology