Author

C. Vieni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. C. Ekiert· 1 shared D. Ekiert· 1 shared G. Bhabha· 1 shared G. L. Isom· 1 shared K. C. O'Connor· 1 shared K. Takata· 1 shared L. Kolich· 1 shared M. L. Fichtner· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

D. C. Ekiert

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2 papers

Recent·Most cited

Role of Ring6 in the function of the E. coli MCE protein LetB

C. Vieni, N. Coudray, G. L. Isom, G. Bhabha, D. C. Ekiert

This study investigates the role of MCE domains in LetB, an E. coli protein, finding that deletion of Ring3 or Ring6 increases resistance to membrane perturbing agents and revealing a model for tunnel gating.

bioRxiv · Sep 30, 2021Biochemistry

Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development

M. L. Fichtner, C. Vieni, R. Redler, L. Kolich, R. Jiang, K. Takata, P. Stathopoulos, P. Suarez, R. J. Nowak, S. J. Burden, D. Ekiert, K. C. O'Connor

The paper investigates how self-antigen-driven affinity maturation contributes to the development of pathogenic monovalent IgG4 autoantibodies in myasthenia gravis, showing that high-affinity Fab-arm exchanged antibodies require specific mutations for pathogenic capacity.

bioRxiv · Mar 14, 2020Immunology