Structural perspective on the design of selective DYRK1B inhibitors
P. Grygier, K. Pustelny, F. Menezes, M. Jemiola-Rzeminska, P. Suder, G. Dubin, A. Czarna
The paper determines the crystal structures of DYRK1B and DYRK1A in complex with AZ191, identifying structural differences that inform selective inhibitor design.
bioRxiv · Dec 23, 2022Biochemistry