J. Plewka

Metaproteogenomics resolution of a high-CO2 aquifer community suggests an active symbiotic lifestyle of groundwater Gracilibacteria

The paper investigates Gracilibacteria activity in a high-CO2 aquifer using metaproteogenomics, suggesting they may function as microbial predators.

Differential expression of core metabolic functions in Candidatus Altiarchaeum inhabiting distinct subsurface ecosystems

This study compares the metatranscriptomes of two Candidatus Altiarchaeum populations in different subsurface ecosystems, identifying gene expression differences related to metabolism and defense mechanisms.

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Heads in the clouds: marine viruses disperse bidirectionally along the natural water cycle

The paper shows marine viruses disperse bidirectionally between air-sea interface ecosystems and rainwater, with genetic evidence of virus-host interactions and implications for atmospheric processes.

Despite the odds: formation of the SARS-CoV-2 methylation complex.

This study demonstrates that SARS-CoV-2 proteins nsp14, nsp10, and nsp16 form a heterotrimer complex, which modulates nsp14's exonuclease activity and protects viral RNA.

Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions

The paper introduces a sensitive NMR competition assay to detect weak inhibitors of protein-protein interactions, demonstrating its use with Mdm2/X-p53 and PD-1/PD-L1 complexes.

CA-170 a potent small-molecule PD-L1 inhibitor or not?

The paper investigates whether CA-170, a small-molecule PD-L1 inhibitor, binds to hPD-L1 using biophysical assays and finds no direct binding.