Author

A. Karim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

A. Czarna· 2 shared A. Matsuda· 2 shared G. Dubin· 2 shared G. Popowicz· 2 shared J. Plewka· 2 shared K. Pyrc· 2 shared L. Kresik· 2 shared M. Pachota· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. Czarna

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Molecular Picture of the Local Environment in a Stable Model Coacervate

A. Baksi, H. Zerze, A. Agrawal, A. Karim, G. H. Zerze

This paper uses molecular dynamics simulations to study ion dynamics in PDDA-ATP coacervates, showing that transferring to DI water causes ion ejection and structural changes that stabilize the coacervates.

bioRxiv · Jan 12, 2024Biophysics

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

A. Czarna, J. Plewka, L. Kresik, A. Matsuda, A. Karim, C. Robinson, S. O Byrne, F. Cunningham, I. Georgiou, M. Pachota, G. Popowicz, P. G. Wyatt, G. Dubin, K. Pyrc

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Structure · Aug 1, 2022Peer-reviewedMicrobiology

Despite the odds: formation of the SARS-CoV-2 methylation complex.

A. Matsuda, J. Plewka, Y. Chykunova, A. N. Jones, M. Pachota, M. Rawski, A. Mourao, A. Karim, L. Kresik, K. Lis, I. Minia, K. Hartman, R. Sonani, G. Dubin, M. Sattler, , A. Czarna

This study demonstrates that SARS-CoV-2 proteins nsp14, nsp10, and nsp16 form a heterotrimer complex, which modulates nsp14's exonuclease activity and protects viral RNA.

bioRxiv · Jan 25, 2022Microbiology

Signature molecular changes in the skeletal muscle of hindlimb unloaded mice

M. Azeem, R. Qiaser, A. Ranade, A. Karim, A. Elmoselhi

This study identifies molecular changes in skeletal muscle of hindlimb unloaded mice using spectroscopy, showing catabolism, tendon repair issues, and sarcoplasmic reticulum stress.

bioRxiv · Oct 30, 2020Biophysics

Modelling early thermal injury using an ex vivo human skin model of contact burns

A. Liu, E. Ocotl, A. Karim, J. J. Wolf, B. L. Cox, K. W. Eliceiri, A. Gibson

This study develops an ex vivo human skin model to simulate contact burns and assesses inter-individual variability in tissue injury and healing over time.

bioRxiv · Aug 18, 2020Cell Biology