Matrix fibril alignment and density modulate YAP-mediated T-cell immune suppression
J. Sapudom, A. Alatoom, P. Tipay, J. Teo
This study shows that dense and aligned collagen matrices suppress T-cell activation via YAP signaling, suggesting ways to improve immunotherapy by modulating T-cell responses in such environments.
bioRxiv · Mar 19, 2024 · PreprintBioengineering