J. Teo

OsHMA3 overexpression works more efficiently in generating low-Cd rice grain than OsNramp5 knockout mutation

This study compares OsNramp5 knockout and OsHMA3 overexpression in reducing grain cadmium in rice, finding OsHMA3 overexpression more effective without impairing manganese uptake.

Matrix fibril alignment and density modulate YAP-mediated T-cell immune suppression

This study shows that dense and aligned collagen matrices suppress T-cell activation via YAP signaling, suggesting ways to improve immunotherapy by modulating T-cell responses in such environments.

Effect of molecular weight of tyramine-modified hyaluronan on polarization state of THP-1 and peripheral blood mononuclear cells-derived macrophages

This paper evaluates how different molecular weights of tyramine-modified hyaluronan affect the polarization of THP-1 and PBMCs-derived macrophages, showing LMW THA drives M1-like polarization while HMW THA induces a mixed profile.

Tissue-bound hyaluronan molecular weight as a regulator of dendritic cell immune potency

This study investigates how different molecular weights of tissue-bound hyaluronan affect dendritic cell functions, finding that low MW HA enhances immature DC differentiation and antigen uptake, while medium and high MW HA increase cytokine secretion in matured DCs.

Nuclear Myosin 1 regulates platelet activation and immune response: A novel therapeutic target for hematologic disorders

This study shows that Nuclear Myosin 1 (NM1) regulates hematopoiesis and immune response, with NM1 deletion causing metabolic shifts and impaired blood cell function, suggesting NM1 as a therapeutic target for hematologic disorders.

Environmental and genetic disease modifiers of haploinsufficiency of A20

The paper identifies genetic and environmental modifiers that exacerbate autoinflammatory disease caused by A20 haploinsufficiency in humans.

bioPROTACs establish RAS as a degradable target and provide novel RAS biology insights

The paper demonstrates that RAS proteins can be degraded using bioPROTACs and provides insights into the functional consequences of RAS degradation and mutant susceptibility.

bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)

This paper introduces bioPROTACs as intracellular biologics for targeted protein degradation, demonstrating their effectiveness against PCNA with rapid degradation and functional effects.

Development and evaluation of a rapid on-site water pathogen detection system for water quality monitoring

This paper develops a rapid on-site DNA-based detection system for Pseudomonas aeruginosa with high sensitivity and specificity, reducing detection time to 45 minutes.