Glucose intake hampers PKA-regulated HSP90 chaperone activity
Y.-C. Chen, P.-H. Jiang, H.-M. Chen, C.-H. Chen, Y.-T. Wang, Y.-J. Chen, C.-J. Yu, S.-C. Teng
The paper identifies Ids2 as a regulator of HSP90 chaperone activity, showing that glucose intake inhibits its function, linking nutrient sensing to proteostasis and longevity.
bioRxiv · Jul 24, 2018Cell Biology