Author

Y.-T. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Samuels· 1 shared A. Smirnov· 1 shared A. Swain· 1 shared A. Trzeciak· 1 shared C. D. Lucas· 1 shared C. H. Wasserfall· 1 shared C. J. Mann· 1 shared C. L. Stallings· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

A. Samuels

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Autophagy protects against high-dose Mycobacterium tuberculosis infection

S. Feng, E. M. Nehls, R. L. Kinsella, S. M. Chavez, S. K. Naik, S. R. McKee, N. Dubey, A. Samuels, A. Swain, X. Cui, S. V. Hendrix, R. Woodson, D. Kreamalmeyer, A. Smirnov, M. N. Artyomov, , C. L. Stallings

This study shows autophagy in myeloid cells protects against high-dose Mycobacterium tuberculosis infection by limiting myeloid-derived suppressor cells and promoting T cell responses, distinct from its role in low-dose infection.

bioRxiv · Nov 4, 2022Microbiology

Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Y.-T. Wang, A. Trzeciak, W. S. Rojas, P. Saavedra, Y.-T. Chen, R. Chirayil, J. I. Etchegaray, C. D. Lucas, D. J. Puleston, K. R. Keshari, J. S. A. Perry

This study identifies two macrophage states induced by chronic hypoxia that enhance efferocytosis through metabolic and transcriptional adaptations.

bioRxiv · Aug 4, 2022Immunology

A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics

C.-F. Tsai, Y.-T. Wang, C.-C. Hsu, R. B. Kitata, R. K. Chu, M. Velickovic, R. Zhao, S. M. Williams, W. B. Chrisler, M. L. Jorgensen, R. J. Moore, Y. Zhu, K. D. Rodland, R. D. Smith, C. H. Wasserfall, , T. Liu

This paper introduces a streamlined phosphoproteomics workflow that reduces sample loss and processing time, enabling sensitive detection of phosphopeptides from nanoscale samples.

bioRxiv · Apr 12, 2022Biochemistry

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology

Glucose intake hampers PKA-regulated HSP90 chaperone activity

Y.-C. Chen, P.-H. Jiang, H.-M. Chen, C.-H. Chen, Y.-T. Wang, Y.-J. Chen, C.-J. Yu, S.-C. Teng

The paper identifies Ids2 as a regulator of HSP90 chaperone activity, showing that glucose intake inhibits its function, linking nutrient sensing to proteostasis and longevity.

bioRxiv · Jul 24, 2018Cell Biology