The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

G3 Genes Genomes Genetics · Sep 13, 2024Peer-reviewedGenetics

Sarbecovirus disease susceptibility is conserved across viral and host models

Sarah R. Leist, Alexandra Schäfer, Ellen L Risemberg, Timothy A. Bell, Pablo Hock, Mark R. Zweigart, Colton L. Linnertz, Darla R. Miller, Ginger D. Shaw, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, William S. J. Valdar, Ralph Steven Baric

The paper identifies a genetic locus associated with coronavirus disease susceptibility in mice and shows its relevance to human severe COVID-19 outcomes.

Virus Research · Jun 14, 2024Peer-reviewedGenetics

A mutation in Themis contributes to peanut-induced oral anaphylaxis in CC027 mice

Ellen L Risemberg, Johanna M. Smeekens, Marta C Cruz Cisneros, Brea K. Hampton, Pablo Hock, Colton L. Linnertz, Darla R. Miller, Kelly Orgel, Ginger D. Shaw, Fernando Pardo‐Manuel de Villena, A. Wesley Burks, William S. J. Valdar, Michael D. Kulis, Martin T. Ferris

This study identifies a Themis mutation as a genetic contributor to peanut-induced anaphylaxis in CC027 mice through genetic mapping and immunological analysis.

bioRxiv · Sep 13, 2023 · PreprintGenetics

Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants

James E. Faber, Hua Zhang, James G. Xenakis, Timothy A. Bell, Pablo Hock, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, Wojciech Rzechorzek

The paper identifies genetic variants associated with collateral blood vessel abundance in mice, linking them to potential human disease mechanisms.

Journal of Cerebral Blood Flow & Metabolism · Aug 12, 2023Peer-reviewedGenetics

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis

Brea K. Hampton, Kenneth S. Plante, Alan C. Whitmore, Colton L. Linnertz, Emily A. Madden, Kelsey E. Noll, Samuel P. Boyson, Breantié Parotti, James G. Xenakis, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, Mark T. Heise

The paper identifies MBD1 as a regulator of homeostatic IgG1 levels and marginal zone B cell differentiation through a genetic screen in Collaborative Cross mice.

PLoS Genetics · Dec 27, 2022Peer-reviewedGenetics

Multi-omics analysis identifies drivers of protein phosphorylation

Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew J. Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, João A. Paulo, Steven P. Gygi, Gary A. Churchill

The paper identifies genetic drivers of protein phosphorylation using multi-omics data from mouse tissues, revealing novel interactions and targets of PDK1 in obesity and diabetes.

bioRxiv · Jun 3, 2022 · PreprintGenomics

Host-pathogen genetic interactions underlie tuberculosis susceptibility

Clare M. Smith, Richard E Baker, Megan K. Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M. Bellerose, Andrew J. Olive, Kenan C. Murphy, Kadamba G. Papavinasasundaram, Frederick J. Boehm, Charlotte Jewell Reames, Rachel K. Meade, , Christopher M. Sassetti

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

eLife · Feb 3, 2022Peer-reviewedMicrobiology

Regulation of protein abundance in genetically diverse mouse populations

Gregory R. Keele, Tian Zhang, Duy T. Pham, Matthew J. Vincent, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, João A. Paulo, Steven C. Munger, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, Steven P. Gygi, Gary A. Churchill

The paper analyzes liver proteomes across three genetically diverse mouse populations to understand how genetic variation influences protein abundance and its relationship to phenotypes.

Cell Genomics · Sep 3, 2021Peer-reviewedGenomics

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

John Sebastian Sigmon, Matthew W Blanchard, Ralph Steven Baric, Timothy A. Bell, Jennifer Brennan, Gudrun A. Brockmann, A. Wesley Burks, J. Mauro Calabrese, Kathleen M. Caron, Richard E. Cheney, Dominic J. Ciavatta, Frank L. Conlon, David B. Darr, James E. Faber, Craig L. Franklin, , Fernando Pardo‐Manuel de Villena

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

Genetics · Oct 17, 2020Peer-reviewedGenetics

Collaborative Cross Mouse Populations as a Resource for the Study of Epilepsy

Bin Gu, John R. Shorter, Lucy H. Williams, Timothy A. Bell, Pablo Hock, Katherine A. Dalton, Yiyun Pan, Darla R. Miller, Ginger D. Shaw, Brian C. Cooley, Benjamin D. Philpot, Fernando Pardo‐Manuel de Villena

The paper uses Collaborative Cross mice to identify genetic loci and candidate genes associated with epilepsy traits, providing resources for studying seizure outcomes and developing new therapies.

bioRxiv · Jul 15, 2019 · PreprintNeuroscience