Systems BiologybioRxivPreprint
Leishmania major centrin knock-out parasites alter the Kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response
Timur Oljuskin, Nazli Azodi, Greta Volpedo…·Hira Lal Nakhasi
This study shows that Leishmania major centrin knock-out parasites alter host tryptophan metabolism to reduce kynurenine-AhR signaling and induce a pro-inflammatory response.