Author

Perianne Smith

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Charles L. SawyersiD· 3 shared Anuradha GopalaniD· 2 shared Dana Pe’eriD· 2 shared Kayla E. LawrenceiD· 2 shared Ning FaniD· 2 shared Rodrigo RomeroiD· 2 shared Ronan ChaligneiD· 2 shared Wenfei Kang· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Charles L. SawyersORCID

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3 papers

Recent·Most cited

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development

Young Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz, Max Land, Roshan Sharma, Joseph Chan, Perianne Smith, Sanjay V. Kottapalli, Linda E. Fong, Zhenghao Chen, Eric Huttenlocher Bent, HuiYong Zhao, Elisa de Stanchina, Wenfei Kang, Shevin Narine, , Charles L. Sawyers

This study identifies an IL-1β/IL-6 signaling circuit in the tumor microenvironment that drives prostate cancer progression from pre-invasive to invasive stages.

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

BRCA2 reversion mutation-independent resistance to PARP inhibition in prostate cancer through loss of function perturbations in the DNA pre-replication complex

Kyrie Pappas, Matteo Ferrari, Perianne Smith, Subhiksha Nandakumar, Zahra Khan, Serina B Young, Justin R. LaClair, Marco Vincenzo Russo, Emmet Huang-Hobbs, Nikolaus D. Schultz, Wassim M. Abida, Wouter R. Karthaus, Maria Jasin, Charles L. Sawyers

This study identifies loss of function mutations in the DNA pre-replication complex as a mechanism for PARP inhibitor resistance in BRCA-mutant prostate cancer, independent of reversion mutations.

bioRxiv · Apr 20, 2025 · PreprintCancer Biology

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

Rodrigo Romero, Tinyi Chu, Tania J González-Robles, Perianne Smith, Yubin Xie, Harmanpreet Kaur, Sara Yoder, Huiyong Zhao, Chenyi Mao, Wenfei Kang, Maria V. Pulina, Kayla E. Lawrence, Anuradha Gopalan, Samir Zaidi, Kwangmin Yoo, , Charles L. Sawyers

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Nature Cancer · Oct 11, 2024Peer-reviewedCancer Biology