Author

Peter M. Chiknas

University of Pittsburgh

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Systems Biology· 1

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Approach:statistical model· 1

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A Hyun KimiD· 1 shared Chaitanya S. MokashiiD· 1 shared Robin LeeiD· 1 shared Steven W. SmealiD· 1 shared

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2025-2025 · peak 1/yr

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A Hyun KimORCID

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1 paper

Recent·Most cited

Systems BiologyNature CommunicationsPeer-reviewedAug 8, 2025

Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics

Steven W. Smeal, Chaitanya S. Mokashi, A Hyun Kim…·Robin Lee

The paper shows that prolonged IKK activation from time-varying cytokine stimuli leads to nuclear NF-κB retention via chromatin remodeling, with simulations accurately predicting single-cell responses.

4 citations

statistical model

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