BioinformaticsGenome biologyPeer-reviewed
Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens
Jean‐Philippe Fortin, Jenille Tan, Karen E. Gascoigne…·Scott E. Martin
The paper analyzes how multi-target sgRNAs in CRISPR screens introduce biases in essentiality scores and functional networks.
43 citations