Cell BiologybioRxivPreprint
Loss of HMGCS2-mediated intestinal stem cell ketogenesis is a metabolic barrier to mucosal healing in Ulcerative colitis
Duncan G. Rutherford, Verity E Cowell, Robert J Whelan…·Gwo‐Tzer Ho
The paper shows loss of HMGCS2-mediated ketogenesis in intestinal stem cells impairs mucosal healing in Ulcerative colitis and identifies {beta}HB as a potential therapeutic target.