mtDNA Activates AIM2-Mediated PANoptosis in Interstitial Macrophages to Promote Immune Checkpoint Inhibitor Pneumonitis
Guodong Wu, Xueping Wei, Jiacheng Jiang, Ping Zhu, Tianyuan Xu, Yakun Weng, Long Shuang Huang
This study shows that mtDNA triggers AIM2-mediated PANoptosis in lung interstitial macrophages, contributing to immune checkpoint inhibitor pneumonitis.
bioRxiv · Oct 16, 2026 · PreprintImmunology