Zinaida Good

The paper uses synthetic cytokine receptor pairings to generate novel T cell states with distinct functions, revealing how pairing orientation and STAT combinatorics influence cell fate.

Gold-nanorod surface-enhanced Raman spectroscopy with LightGBM separates CAR T from untransduced T cells, tracks antigen-specific activation dynamics, and discriminates sorted CAR+ from CAR- patient T cells.

CellFuse integrates single-cell and spatial proteomics data using a deep learning framework, outperforming existing methods in accuracy and efficiency.

MONTAGE identifies spatially resolved functional enrichment gradients in tumor microenvironments by analyzing spatial communities and their clinical relevance.

CELESTA identifies cell types in multiplexed in situ images by integrating protein expression and spatial information, revealing novel spatial biology associated with lymph node metastasis.

This study shows that overexpressing c-Jun in CAR-T cells reduces exhaustion and improves antitumor activity in vivo.