GenomicsbioRxivPreprint
Reconstructing clone-resolved transcriptional programs from bulk tumor sequencing
Jiaying Lai, Yi Yang, Kathleen Noller…·Rachel Karchin
PICTographPlus infers clone-resolved transcriptional programs from bulk RNA-seq by integrating clonal phylogenies and proportions, achieving high accuracy in recovering clone-level expression and localizing pathway changes.
DOI 10.64898/2026.01.15.699695