Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females
Muriel E. Babey, William C. Krause, Candice B. Herber, Kun Chen, Joni Nikkanen, R Garcia Rodriquez, Xiao Zhang, F Navarro, Yuting Wang, Saul Villeda, Nancy E. Lane, Erica L. Scheller, Charles K. F. Chan, Thomas H. Ambrosi, Holly A. Ingraham
This paper identifies CCN3 as a brain-derived hormone that promotes bone mass in lactating females by compensating for estrogen loss and supporting skeletal stem cells.
bioRxiv · Aug 28, 2023 · PreprintNeuroscience