Cell BiologybioRxiv
Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
L. H. Pearl, N. Bigot, M. Day…·A. Oliver
This study identifies a phosphorylation-dependent interaction between 53BP1 and TOPBP1 that is critical for the G1 DNA damage checkpoint by recruiting ATR and CHK1 to damage foci.
DOI 10.7554/elife.44353