Author

R. B. Cooley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

N. N. Sluchanko· 3 shared A. A. Kapitonova· 2 shared P. Zhu· 2 shared R. A. Mehl· 2 shared A. A. Antson· 1 shared A. A. Sysoev· 1 shared A. B. Estelle· 1 shared A. Rasouli· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

N. N. Sluchanko

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4 papers

Recent·Most cited

Phosphorylation code of human nucleophosmin includes four cryptic sites for hierarchical binding of 14-3-3 proteins

A. A. Kapitonova, K. V. Perfilova, R. B. Cooley, N. N. Sluchanko

This study identifies four phosphorylation sites in NPM1 that enable 14-3-3 protein binding, revealing how phosphorylation regulates NPM1's nucleocytoplasmic shuttling and structural dynamics.

bioRxiv · Feb 13, 2024Biochemistry

Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation

P. Zhu, K. T. Nguyen, A. B. Estelle, N. N. Sluchanko, R. A. Mehl, R. B. Cooley

This study genetically encodes 3-nitro-tyrosine in 14-3-3 proteins to investigate how nitration at Y130 and Y213 affects structure, function, and client binding.

bioRxiv · Nov 11, 2022Biochemistry

Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells

G. D. Galles, D. T. Infield, C. J. Clark, M. L. Hemshorn, S. Manikandan, F. S. Fazan, A. Rasouli, E. Tajkhorshid, J. D. Galpin, R. B. Cooley, R. A. Mehl, C. A. Ahern

This paper introduces new pyrrolysine-based aminoacyl-tRNA synthetase/tRNA pairs to site-specifically encode fluorinated phenylalanine residues in bacterial and mammalian cells, enabling experimental assessment of aromatic-pi interactions.

bioRxiv · Apr 12, 2022 · PreprintBiochemistry

Human 14-3-3 proteins site-selectively bind the mutational hotspot region of SARS-CoV-2 nucleoprotein modulating its phosphoregulation

K. V. Tugaeva, A. A. Sysoev, A. A. Kapitonova, J. L. R. Smith, P. Zhu, R. B. Cooley, A. A. Antson, N. N. Sluchanko

This study shows that 14-3-3 proteins bind specific phosphorylation sites in SARS-CoV-2 nucleoprotein, affecting its phosphoregulation and potentially influencing viral replication.

bioRxiv · Dec 23, 2021Biochemistry