J. D. Galpin

The paper shows that backbone amides in CLC channels are critical for Cl- selectivity, as replacing them with ester groups reduces ion discrimination.

This paper introduces new pyrrolysine-based aminoacyl-tRNA synthetase/tRNA pairs to site-specifically encode fluorinated phenylalanine residues in bacterial and mammalian cells, enabling experimental assessment of aromatic-pi interactions.

This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.