P. Zhu

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse

This study identifies FAM210A as a mediator of mitochondrial-ribosome crosstalk that supports protein synthesis and muscle growth in mice.

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

This study reports the cryoEM structure of an open KATP channel with PIP2 bound, revealing two PIP2 binding sites and their role in channel regulation and neonatal diabetes.

CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptor

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters

The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.

Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals

This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.

Taxonomic and carbon metabolic diversification of Bathyarchaeia during its co-evolution history with the early Earth surface environment

This study investigates the evolutionary history and metabolic diversity of Bathyarchaeia, linking their diversification to geological events and environmental changes.

Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation

This study genetically encodes 3-nitro-tyrosine in 14-3-3 proteins to investigate how nitration at Y130 and Y213 affects structure, function, and client binding.

A host E3 ubiquitin ligase regulates Salmonella virulence by targeting an SPI-2 effector involved in SIF biogenesis

The paper identifies TRIM32 as a host E3 ubiquitin ligase that targets SseK3, an SPI-2 effector, to restrict Salmonella-induced filament biogenesis and replication.

REST: A method for restoring signals and revealing individual macromolecule states in cryo-ET

REST is a deep learning method that restores cryo-ET density maps by denoising and compensating for missing wedge effects, enabling visualization of individual macromolecules.

Cryo-EM structures reveal a dynamic transformation process of human alpha-2-macroglobulin working as a protease inhibitor

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Human 14-3-3 proteins site-selectively bind the mutational hotspot region of SARS-CoV-2 nucleoprotein modulating its phosphoregulation

This study shows that 14-3-3 proteins bind specific phosphorylation sites in SARS-CoV-2 nucleoprotein, affecting its phosphoregulation and potentially influencing viral replication.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

AlphaFold Protein Structure Database for Sequence-Independent Molecular Replacement

The paper tests if AlphaFold-predicted protein structures can be used for sequence-independent molecular replacement in crystallography, successfully determining two unknown contaminant structures.

Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

Silkworm spinning: the programmed self-assembly from natural silk fibroin to superfibre

This study reveals how silkworms use metal ions and pH gradients to drive the self-assembly of silk fibroin nanofibrils into herringbone-like structures for fiber spinning.

rtcisE2F drives liver TIC self-renewal and metastasis via m6A-modulated mRNA stability of E2F6 and E2F3

This paper identifies rtcisE2F as a circRNA that regulates liver TIC self-renewal and metastasis by modulating E2F6 and E2F3 mRNA stability through m6A reader interactions.

Species-resolved sequencing of low-biomass microbiomes by 2bRAD-M

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

The PRC2-dependent epigenetic reprograming of the bladder epithelium exacerbates urinary tract infections

This study shows that PRC2-dependent epigenetic reprogramming in bladder urothelium worsens UTIs by promoting inflammation and impaired differentiation, and that inhibiting Ezh2 can improve disease outcomes.

Longitudinal multi-omics along gingivitis development reveal a suboptimal-health gum state with periodontitis-like microbiome

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

Inducing highly physiologically relevant phenotypes of human vascular smooth muscle cells via 3D printing

This study uses 3D printing to create vessel architectures that induce more physiologically relevant phenotypes in vascular smooth muscle cells compared to 2D cultures.

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

Structural Basis for Ca2+-Dependent Activation of a Plant Metacaspase

This study determines the crystal structure of AtMC4, revealing how Ca2+ activates plant metacaspase through linker domain cleavage and substrate access.

Dysregulated Alternative Splicing Landscape Identifies Intron Retention as a Hallmark and Spliceosome as a Therapeutic Vulnerability in Aggressive Prostate Cancer

The paper identifies intron retention as a hallmark of aggressive prostate cancer and highlights the spliceosome as a therapeutic target by analyzing splicing dysregulation across prostate cancer progression.

Impact of exogenous nitrogen on cyanobacterial abundance and community in oil-contaminated sediment mesocosms

The paper investigates how exogenous nitrogen affects cyanobacterial abundance and community in oil-contaminated sediment mesocosms, finding nitrogen limitation drives cyanobacterial blooms in oil-contaminated environments.