Cell BiologybioRxivPreprint
Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy
F. Borot, O. Humbert, G. A. Newby…·H.-P. Kiem
The paper develops a base editing approach to reduce on-target toxicity in CD33-directed therapies by editing CD33 and gamma globin genes in hematopoietic stem and progenitor cells.
DOI 10.1101/2023.02.23.529353