CD4+ T cells persist for years in the human small intestine and mediate robust Th1 immunity.
R. Bartolome Casado, O. J. B. Landsverk, S. Kumar Chauhan, F. Saetre, K. T. Hagen, S. Yaqub, O. Oyen, R. Horneland, E. M. Aandahl, L. Aabakken, E. S. Baekkevold, F. L. Jahnsen
The paper shows that CD4+ T cells persist in the human small intestine for over a year and are mainly Th1 cells, with implications for gut-targeted vaccines and therapies.
bioRxiv · Dec 3, 2019 · PreprintImmunology