Y. Yao

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

This study shows that Gγ13 signaling in tuft cells is essential for resolving lung inflammation and promoting recovery after severe injury.

Dihydromyricetin promotes GLP-1 secretion to improve insulin resistance via "gut microbiota-CDCA"

This study shows that dihydromyricetin improves insulin resistance by enhancing GLP-1 secretion through the gut microbiota-CDCA pathway in HFD-induced mice.

Spatiotemporal dynamic models of Amblyomma americanum questing activity in the Central Great Plains

This study models the spatiotemporal dynamics of Amblyomma americanum questing activity using longitudinal sampling, randomization tests, and presence-absence modeling to improve understanding of tick-borne disease risk.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

Arsinothricin Biosynthesis Involving a Noncanonical Radical SAM Enzyme for C-As Bond Formation

This paper characterizes ArsL, a noncanonical radical SAM enzyme involved in arsinothricin biosynthesis, showing it cleaves SAM to generate an ACP radical and reconstitutes the pathway in vitro.

Using split protein reassembly strategy to control PLD enzymatic activity

This study uses split protein reassembly and optogenetic techniques to control PLD enzymatic activity by modulating domain interactions.

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

Deciphering the gut microbiome of grass carp through multi-omics approach

The paper uses a multi-omics approach to analyze the gut microbiome of grass carp, identifying two functional groups and proposing a biomarker for microbiota structure and function.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

Elevation-dependent patterns of snow-gum dieback are moderated by trait differences between montane and subalpine forests.

The paper examines elevation-dependent patterns of snow-gum dieback and finds trait differences between montane and subalpine subspecies influence borer-damage severity.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Immediate impact of the 2021 harmful algal bloom in southeast Hokkaido on the rocky intertidal community and its spatial variation

This study examines the immediate effects of a 2021 harmful algal bloom on rocky intertidal species abundance and spatial variation in southeast Hokkaido.

Tropism of AAV.CPP.16 in the respiratory tract and its application for a CRISPR-based gene therapy against SARS-CoV-2

This study evaluates AAV.CPP.16 as a gene delivery vector for respiratory diseases and demonstrates its use in a CRISPR-based therapy targeting SARS-CoV-2.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

Identifying Temporal Correlations Between Natural Single-shot Videos and EEG Signals

The paper identifies temporal correlations between natural single-shot videos and EEG signals, showing that object-based features outperform traditional video features in capturing these correlations.

Comparative Analysis of Multiple Consensus Genomes of the Same Strain of Marek's Disease Virus Reveals Intrastrain Variation

This study compares multiple consensus genomes of the same Marek's Disease Virus strain, revealing intrastrain variation and highlighting the need for multiple genomes to improve interstrain comparisons.

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation

This study investigates how TGF-β1 and cholesterol interact to influence hepatocyte fate, EMT, and HSC activation in MASLD.

Optogenetic strategies for optimizing the performance of biosensors of membrane phospholipids in live cells

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

Modeling of lung-liver interaction during infection in a human microfluidic organ-on-a-chip

This study develops a lung-liver microfluidic system to investigate inter-organ interactions during infection, showing bacterial stimulation of lung cells alters liver gene expression.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Effect of Intermittent Pneumatic Compression on Preventing Deep Vein Thrombosis Using Microfluidic Vein Chip

The paper develops a microfluidic vein chip to simulate IPC effects and identifies optimal parameters for DVT prevention.

Coronary Artery Disease Risk Gene PRDM16 is Preferentially Expressed in Vascular Smooth Muscle Cells and a Potential Novel Regulator of Smooth Muscle Homeostasis

This study identifies PRDM16 as a novel regulator of vascular smooth muscle cell homeostasis, showing its preferential expression in contractile VSMCs and its role in modulating CAD risk genes.

Dynamics of vegetation cover and its driving factors in the Qinling-Daba Mountains on regional scale for 1986-2019

This study analyzes vegetation cover dynamics and driving factors in the Qinling-Daba Mountains from 1986 to 2019 using satellite data and spatial analysis.

Mutual regulation of transcriptomes between pneumocytes and fibroblasts mediates alveolar regeneration

The paper shows that co-culturing fibroblasts with pneumocytes enhances epithelial markers and barrier function, while fibroblasts upregulate IL-6 and other factors, suggesting mutual regulation in alveolar regeneration.