Author

S. Yaqub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:flow cytometry· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

F. L. Jahnsen· 4 shared E. M. Aandahl· 3 shared E. S. Baekkevold· 3 shared O. J. B. Landsverk· 3 shared R. Horneland· 3 shared D. Phung· 2 shared F. Saetre· 2 shared J. Jahnsen· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

F. L. Jahnsen

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Author profile →

5 papers

Recent·Most cited

Affinity-engineered human antibodies detect celiac disease gluten pMHC complexes and inhibit T-cell activation

R. Frick, L. S. Hoydahl, I. Hodnebrug, S. Kumari, G. Berntsen, J. R. Jeliazkov, K. S. Gunnarsen, T. Frigstad, E. S. Vik, K. E. A. Lundin, S. Yaqub, J. Jahnsen, J. J. Gray, L. M. Sollid, I. Sandlie, G. A. Loset

The paper describes the engineering of high-affinity human antibodies that recognize gluten epitopes bound to HLA-DQ2.5 and inhibit T-cell activation in celiac disease.

Science Immunology · Aug 10, 2021Peer-reviewedImmunology

Spatiotemporal single cell transcriptomic analyzis of human gut macrophages revealsmultiple functional and niche-specific subsets

D. Domanska, U. Majid, V. T. Karlsen, M. A. Merok, A.-C. Beitnes, S. Yaqub, E. S. Bakkevold, F. L. Jahnsen

The paper identifies multiple functional subsets of gut macrophages using single-cell transcriptomics and shows their niche-specific roles in tissue homeostasis.

bioRxiv · May 11, 2021Immunology

The human small intestine contains two subsets of regulatory Foxp3+ CD4+ T cells with very different life span and functional properties.

S. K. Chauhan, R. B. Casado, O. J. B. Landsverk, H. Johannessen, D. Phung, F. Saetre, J. Jahnsen, R. Horneland, S. Yaqub, E. M. Aandahl, K. E. A. Lundin, E. S. Baekkevold, F. L. Jahnsen

This study identifies two distinct subsets of Foxp3+ CD4+ Tregs in the human small intestine with different functional properties and lifespans, which expand in celiac disease.

bioRxiv · Feb 12, 2020 · PreprintImmunology

CD4+ T cells persist for years in the human small intestine and mediate robust Th1 immunity.

R. Bartolome Casado, O. J. B. Landsverk, S. Kumar Chauhan, F. Saetre, K. T. Hagen, S. Yaqub, O. Oyen, R. Horneland, E. M. Aandahl, L. Aabakken, E. S. Baekkevold, F. L. Jahnsen

The paper shows that CD4+ T cells persist in the human small intestine for over a year and are mainly Th1 cells, with implications for gut-targeted vaccines and therapies.

bioRxiv · Dec 3, 2019 · PreprintImmunology

Resident memory CD8 T cells persist for years in human small intestine

R. Bartolome Casado, O. J. B. Landsverk, S. K. Chauhan, L. Richter, D. Phung, V. Greiff, L. F. Risnes, Y. Yao, R. S. Neumann, S. Yaqub, O. Oyen, R. Horneland, E. M. Aandahl, V. Paulsen, L. M. Sollid, , F. L. Jahnsen

The paper identifies that most CD8 T cells in the human small intestine are resident memory cells that persist for over a year and maintain a stable TCR repertoire.

bioRxiv · Feb 19, 2019Immunology