Autotaxin facilitates selective LPA receptor signaling
F. Salgado-Polo, R. Borza, F. Marsais, C. Jagerschmidt, L. Waeckel, W. H. Moolenaar, P. Ford, B. Heckmann, A. Perrakis
This study shows that ATX inhibitors targeting the ATX tunnel selectively block LPA signaling via P2Y receptors, with implications for pulmonary fibrosis treatment.
bioRxiv · Apr 9, 2022Cell Biology