Author

R. Bosma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

C. de Graaf· 2 shared M. Arimont-Segura· 2 shared R. Leurs· 2 shared A. Chevigne· 1 shared A. D. Windhorst· 1 shared A. Zarca· 1 shared B. A. Zarzycka· 1 shared B. Zarzycka· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

C. de Graaf

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2 papers

Recent·Most cited

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

O. Otun, C. Aljamous, E. Del Nero, M. Arimont-Segura, R. Bosma, B. Zarzycka, T. Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, X. Cong, C. BECHARA

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Pharmacological characterization and radiolabeling ofVUF15485, a high-affinity small-molecule agonist for theatypical chemokine receptor ACKR3

A. Zarca, I. Adlere, C. P. Viciano, M. Arimont-Segura, M. Meyrath, I. A. Simon, J. P. M. Bebelman, D. Laan, H. G. J. Custers, E. C. Janssen, K. L. Versteegh, R. Bosma, I. J. P. De Esch, H. F. Vischer, M. Wijtmans, , R. Leurs

This paper characterizes VUF15485, a high-affinity ACKR3 agonist, and reports its radiolabeling and binding properties.

bioRxiv · Jul 12, 2023Pharmacology & Toxicology