BiochemistrybioRxiv
Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin
D. Susan-Resiga, E. Girard, R. Essalmani…·N. G. Seidah
This paper identifies ASGR1 as a novel PCSK9-independent ligand of liver LDLR that is shed by Furin, leading to reduced LDLR levels and LDL uptake.
DOI 10.1016/j.jbc.2021.101177