Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
X. Zhang, T. Das, T. F. Chao, V. Trinh, R. Carmen, J. P. Ling, P. Kalab, L. R. Hayes
This study shows that multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus, forming high molecular weight RNPs, but pure GU-repeats impair TDP-43 function.
bioRxiv · Aug 1, 2023Cell Biology