T. Das

The S-lignin O-demethylase SyoA: Structural insights into a new class of heme peroxygenase enzymes

This paper characterizes the structure and function of SyoA, a heme peroxygenase enzyme that demethylates S-lignin aromatics via the peroxide shunt pathway, revealing key residues critical for its activity.

Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

Amplification of avian influenza viruses along poultry marketing chains in Bangladesh: a controlled field experiment

The study shows that avian influenza virus prevalence in chickens increases after arrival at live bird markets, partly due to infections during transport and trade.

Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition

This study identifies a mechanical imbalance between normal and transformed cells in epithelial tissue, showing that transformed cells are more compressible due to weakened adhesions, driving cell competition and homeostasis.

Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes

This study shows that multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus, forming high molecular weight RNPs, but pure GU-repeats impair TDP-43 function.

Matrix stiffening promotes perinuclear clustering of mitochondria

This study shows that matrix stiffness causes mitochondria to cluster around the nucleus in human mesenchymal stem cells, which is important for osteogenesis on stiff matrices.

Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation

This paper reveals a density-dependent collective metabolic heterogeneity in epithelial cells during contact inhibition of proliferation, showing distinct metabolic patterns in different stages.

Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL

The paper identifies LUBAC-mediated M1 ubiquitination as a species-specific checkpoint regulating necroptosis by controlling MLKL membrane accumulation in human cells and organoids.

Prediction of Golgi Polarity in Collectively Migrating Epithelial Cells Using Graph Neural Network

The paper uses a graph neural network to predict Golgi polarity in migrating epithelial cells, finding it correlates with stress orientation and is affected by local stress field coarsening.

Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence in collective cell migration

The paper identifies lysosomal dynamics along microtubules as critical for leader cell emergence in collective cell migration by modulating Rac1 activity and actin polymerization.

Spatial-transcriptomics reveals unique defining molecular features of fluorescence-sorted 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survival

The paper uses spatial transcriptomics to identify molecular features of 5ALA+ infiltrative tumor cells in glioblastoma linked to recurrence and poor survival.

Acceleration of enzymatic catalysis by active hydrodynamic fluctuations

The paper investigates how active hydrodynamic fluctuations influence enzymatic catalytic rates, finding that fast noise components enhance reaction rates while slow components have little effect.

Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.

Expression of Toll like Receptor 4 in the ductal epithelial cells of the Breast tumor microenvironment is correlated with the invasiveness of the tumor

The paper investigates TLR4 expression in breast tumors and finds it correlates with invasiveness and lymph node involvement, with differential effects in TP53 wild-type and mutant cells.

Regulation of Exocytosis and Mitochondrial Relocalization by Alpha-Synuclein in a Mammalian Cell Model

This study shows that alpha-synuclein expression affects exocytosis in mast cells, with structural mutants impacting membrane interactions and mitochondrial association under stress.