Systems BiologyScience SignalingPeer-reviewed
MAPK and mTORC1 signaling converge on Cyclin D to enable cell-cycle re-entry in melanoma persister cells
Varuna Nangia, Humza M. Ashraf, Nasreen C. Marikar…·Sabrina L. Spencer
The paper identifies Cyclin D1 accumulation as a critical bottleneck for cell-cycle re-entry in drug-treated melanoma cells, driven by MAPK and mTORC1 signaling integration.