Author

R. E. Bainbridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Xenopus· 3 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. E. Carlson· 4 shared J. C. Rosenbaum· 2 shared K. M. Komondor· 2 shared A. Stsiapanava· 1 shared B. W. Wisner· 1 shared B. Wiseman· 1 shared C. Emori· 1 shared C. H. Luu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPhysiology

A. E. Carlson

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Author profile →

4 papers

Recent·Most cited

BiophysicsbioRxivJun 21, 2023

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

S. Nishio, C. Emori, B. Wiseman…·L. Jovine

This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.

DOI 10.1016/j.cell.2024.02.013

mousestructural biology

PhysiologybioRxivPreprintFeb 2, 2023

Xenopus laevis lack the critical sperm factor PLCζ

R. E. Bainbridge, J. C. Rosenbaum, P. Sau, A. E. Carlson

This study investigates whether Xenopus laevis sperm express an unannotated PLCZ1 ortholog, finding none and suggesting PLCZ1 may have been lost in the Xenopus lineage.

DOI 10.1101/2023.02.02.526858

Xenopusbulk RNA-seq

PhysiologybioRxivAug 30, 2022

TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs

K. M. Komondor, R. E. Bainbridge, K. G. Sharp…·A. E. Carlson

This study investigates the mechanism by which fertilization activates PLC in Xenopus laevis eggs to trigger the fast block to polyspermy, finding no effect from inhibitors of PLCγ or Gq/11 pathways.

DOI 10.1085/jgp.202213258

Xenopuselectrophysiology

PhysiologybioRxivJun 8, 2020

Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals

K. L. Wozniak, R. E. Bainbridge, D. W. Summerville…·A. E. Carlson

The paper shows that zinc release by eggs to block polyspermy is an ancient reproductive strategy across multiple animal phyla.

DOI 10.1371/journal.pbio.3000811

XenopusC. elegans