Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
C. J. Brereton, L. Yao, Y. Zhou, M. Vukmirovic, J. A. Bell, R. A. Ridley, E. Davies, L. S. N. Dean, O. G. Andriotis, F. Conforti, S. Mohammed, T. Wallis, A. Tavassoli, R. Ewing, A. Alzetani, , M. Jones
This study shows that pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by promoting bone-type cross-linking and increasing tissue stiffness.
bioRxiv · May 11, 2021Cell Biology