L. Yao

Automated and high throughput measurement of leaf stomatal traits in canola

SCAN measures canola stomatal traits with 89-94% accuracy using YOLOv8 and digital microscopy, and predicts traits in other species.

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

Gradual labeling with fluorogenic probes for MINFLUX nanoscopy of densely packed structures

This paper introduces GLF-MINFLUX, a method for nanoscale imaging of densely packed structures, achieving improved localization precision and faster acquisition.

Limit of detection of Salmonella ser. Enteritidis using culture-based versus culture-independent diagnostic approaches

This study compares the limit of detection of Salmonella ser. Enteritidis using culture-based and culture-independent methods, finding comparable LOD50 for qPCR and shotgun sequencing, but false positives in unspiked samples and lower LOD50 in feed than caecal contents.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis

This study shows that warm temperatures suppress systemic acquired resistance in plants by reducing N-hydroxypipecolic acid biosynthesis, affecting both local and systemic immunity.

A bioactive peptide from the pearl has dual roles in resisting SARS-CoV-2 infection and its complications

This study identifies a bioactive peptide from a pearl oyster that inhibits SARS-CoV-2 infection and enhances ACE2 activity to treat related complications.

Efficacy of the first bioactive peptide from the pearl

The paper identifies a novel ACE-inhibitory peptide from pearl matrix and demonstrates its potential as an antihypertensive agent.

Percutaneous Intramyocardial Septal Cryoablation: A Canine Model with 6 months Follow-up

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

This study shows IL-33 reduces IL-22 production in innate lymphoid cells, increasing resistance to Streptococcus pneumoniae infection, and links genetic variation in IL-33 signaling to human pneumonia.

Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus

This study uses single cell RNA sequencing to identify distinct subpopulations of notochord-derived nucleus pulposus cells in postnatal mice, revealing developmental stages and molecular signatures associated with extracellular matrix production.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

CAM5, WRKY53, and TGA5 regulate defense gene expression mediated by the volatile organic compound ethyl vinyl ketone

This paper identifies ethyl vinyl ketone (evk) as a signaling molecule in Arabidopsis thaliana, showing it activates defense genes via CAM5, WRKY53, and TGA5 through Ca2+ and H2O2 signaling.

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

Ring-finger protein 34 facilitates nervous necrosis virus evading antiviral innate immunity by targeting TBK1 and IRF3 for ubiquitination and degradation

This paper identifies RNF34 as a viral E3 ubiquitin ligase that suppresses antiviral innate immunity by degrading TBK1 and IRF3, facilitating NNV replication.

High air humidity dampens salicylic acid pathway and plant resistance via targeting of NPR1

This study shows high air humidity reduces plant resistance by inhibiting salicylic acid signaling through altered NPR1 protein function in Arabidopsis.

Genomic data support Betula halophila and Betula microphylla as one species and reveal unidirectional introgression from Betula pendula to Betula microphylla

The paper uses RADseq to show Betula halophila and Betula microphylla are one species, with introgression from B. pendula to B. microphylla, and identifies salt-tolerance genes in introgressed regions.

Activin A promotes bone fracture repair and acts through a novel myofibroblastic cell population in callus

This study identifies activin A's role in bone fracture repair by promoting a novel myofibroblastic progenitor cell population that drives chondrogenesis and osteogenesis.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

More than 90% of nacre matrix proteins are composed of silk-like proteins

The paper identifies silk-like proteins as the main components of nacre matrix proteins, showing over 90% composition in both soluble and insoluble fractions.

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

This study creates a multi-scale, multiomic atlas of human normal and follicular lymphoma lymph nodes to identify tumor-specific features and microenvironmental patterns associated with early relapse.

Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquito populations from Abidjan, Cote d'Ivoire

This study evaluates the efficacy of Fludora Co-Max EW against insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquitoes in Abidjan, finding it more effective than K-Othrine EC in both outdoor and indoor settings.

An overlapped natural antisense lncRNA FCER1A-AS controls anaphylactic reaction by promoting FcϵRIα expression

This study identifies FCER1A-AS, an antisense lncRNA, as a regulator of FcϵRIα expression, which is critical for anaphylactic reactions.

Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

This study identifies bi-steric mTORC1-selective inhibitors that reactivate 4EBP1, suppress MYC-driven tumors, and enhance immunotherapy in multiple cancer models.

Comparing the folding landscapes of evolutionarily divergent procaspase-3

This study compares the folding landscapes of zebrafish and human effector procaspase-3, showing conserved folding pathways with species-specific intermediate stability.

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.