S. Mohammed

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer cells

This paper introduces 13C-SpaceM, a method for spatial single-cell isotope tracing of de novo fatty acid synthesis in cancer cells, revealing metabolic heterogeneity in liver and glioma tissues.

Entanglement of AGE-RAGE axis in cardiac pathosis

This study investigates the cardioprotective effects of rosuvastatin in isoproterenol-induced myocardial injury and shows that it inhibits the AGE-RAGE axis, reducing cardiac damage markers and inflammation.

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

This study identifies nuclear RNA-binding proteins that are translocated to the cytoplasm during alphavirus infection and exhibit antiviral activity.

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

This study shows that necroptosis increases with age in the liver, contributing to chronic inflammation and fibrosis.

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

This study shows that pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by promoting bone-type cross-linking and increasing tissue stiffness.

Colicin-mediated transport of DNA through the iron transporter FepA

This study shows colicin B uses the iron transporter FepA to transport DNA into E. coli, revealing a mechanism for cargo delivery through bacterial membranes.

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection

The paper identifies key host and viral RNA-binding proteins involved in SARS-CoV-2 infection and shows that drugs targeting these proteins can inhibit infection.

Structural characterisation of KKT4, an unconventional microtubule-binding kinetochore protein

This study characterizes the structure and dynamics of KKT4, a kinetoplastid kinetochore protein, revealing its microtubule-binding domain and DNA-binding properties.

Role of necroptosis in chronic hepatic inflammation and liver disease in Cu/Zn superoxide dismutase deficient mice

This study shows that necroptosis contributes to liver inflammation, fibrosis, and HCC progression in Sod1KO mice by increasing pro-inflammatory markers and STAT3 activation.

Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

The paper uses mass spectrometry to show that selective proteolysis of cyclin B initiates dephosphorylation events that drive mitotic exit.

Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

This study shows that destabilizing the HIV-1 capsid lattice leads to premature loss of the viral genome and integrase enzyme in infected cells.

Morphologically and physiologically diverse fruits of two Lepidium species differ in allocation of glucosinolates into immature and mature seed and pericarp

This study compares glucosinolate allocation in fruits of two Lepidium species with different dispersal strategies and dormancy status, finding differences in concentration and class distribution between immature and mature tissues.

Translational control of TFEB and autophagy via eIF5A rejuvenates B cell immunity

This study identifies a mechanism by which spermidine regulates autophagy through eIF5A-mediated TFEB translation, improving B cell immunity in aging.