Structural basis for feedforward control in the PINK1/parkin pathway
V. Sauve, G. Sung, E. MacDougall, G. Kozlov, A. Saran, R. Fakih, E. A. Fon, K. Gehring
The paper elucidates how phospho-ubiquitin binds to parkin's RING domains to activate the PINK1/parkin pathway through a feedforward mechanism.
bioRxiv · Aug 16, 2021Biochemistry